| Department of Bacic Animal and Veterinary Sciences
90 % Department of Plant Biology and Biotechnology 5 % Department of Agriculture and Ecology 5 % | |||||||||||||||||
| Earliest Possible Year | BSc. 2 year | ||||||||||||||||
| Duration | One block | ||||||||||||||||
| Credits | 7.5 (ECTS) | ||||||||||||||||
| Course Level | Joint BSc and MSc | ||||||||||||||||
| Examination | oral examination All aids allowed Description of Examination: The 20 min. oral examination, is based on the theoretical case studies, on the practical laboratory work and on the textbook pages given as examination requirements. The oral exam is divided into 10 min. on a report related subject and 10 min. on a text book related subject. Both subject are drawn at the beginning of the examination, no preparation. Weight: 100% 7-point scale, internal examiner | ||||||||||||||||
| Requirement For Attending Exam | An approved written report is prerequisite for access to the oral examination. The oral exam does not include time for preparation, but notes are allowed | ||||||||||||||||
| Organisation of Teaching | Lectures, case work, theoretical and practical exercises, group presentation | ||||||||||||||||
| Block Placement | Block 1 Week Structure: A | ||||||||||||||||
| Teaching Language | English | ||||||||||||||||
| Optional Prerequisites | Genetics 1, Genetics 2/animal genetics | ||||||||||||||||
| Restrictions | 20 | ||||||||||||||||
| Course Contents | |||||||||||||||||
| The following topics will be covered in the theoretical part of the course: 1) Genome projects 2) The mammalian genome 3) Comparative genomics 4) Gene mapping 5) Mapping of diasease genes 6) Gene expression 7) Molecular pathology/Cancer 8) Beyond the genome projects 9) Genetic testing 10)Genetic manipulation of cells and animals 11)microRNAs The case work will focus on the gene that forms the basis for the practical part of the course. The practical part of the course will contain: 1) DNA sequence analysis (PC-lab) 2) Gene mapping (lab work) 3) Gene expression (lab work) 4) Western blotting (lab work) More information will be given at the beginning of the course. | |||||||||||||||||
| Teaching And Learning Methods | |||||||||||||||||
| Lectures, case work, theoretical and practical exercies, group presentations and group discussions | |||||||||||||||||
| Learning Outcome | |||||||||||||||||
| Course Objectives The course is an advanced course in theoretical and practical genomics with focus on mammals. The course will provide information that will allow the student to gain knowledge on methods and technologies currently used to dissect, describe and characterise complex genomes. Aspects of both research and application within the field of genomics will be addressed. Learning Outcome After completion of the course the student is expected to have: Knowledge and understanding The student should be able to describe the architecture and components of an average mammalian genome. He/she should be able to understand the possibilities of analysing and characterizing mammalian genomes, and to understand qualitative and quantitative genetics with focus on mammalian disease genetics. He/she should be able to describe the technologies and methods involved in genome projects and the objectives of the different genome projects. Furthermore, he/she should understand how comparative genomics can be used in the characterisation of genomes and how comparative genomics can be used to transfer genomic information from one species to another, and understand the regulation of gene expression on different levels. Finally, he/she should understand how mutations can cause inherited defects and predisposition to disease such as cancer and the possibilities and relevance of genetic testing, and know how genomes are annotated. Skills Use of basic and advanced methods in molecular genetics. Perform DNA sequence analysis, simple sequence assembly and annotation and detect sequence variation. Perform PCR Perform gene mapping in hybrid panel Perform quantitative PCR and analyse expression profiles of genes in different tissues Perform western blotting Competences Evaluation of strategies to dissect the genetics underlying inherited traits in mammals. Evaluate the practical use of genetic testing. | |||||||||||||||||
| Course Litterature | |||||||||||||||||
| Human Molecular Genetics.Third Edition. Tom Strachan, Andrew P. Read. 11/21/2003. 696 pages. Handouts | |||||||||||||||||
| Course Coordinator | |||||||||||||||||
| Susanna Cirera, scs@life.ku.dk, Department of Basic Animal and Veternary Sciences/Genetics & Bioinformatics, Phone: 35333050 Claus Bøttcher Jørgensen, chj@life.ku.dk, Department of Basic Animal and Veternary Sciences/Genetics & Bioinformatics, Phone: 35333064 | |||||||||||||||||
| Study Board | |||||||||||||||||
| Study Committee NSN | |||||||||||||||||
| Course Scope | |||||||||||||||||
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